In this article, we will explore the topic of Tetrahydrodeoxycorticosterone in depth, analyzing its origins, impact on society, and possible implications for the future. Tetrahydrodeoxycorticosterone is a topic that has captured the attention of experts and amateurs alike, generating debates and discussions in different areas of knowledge. Over the years, Tetrahydrodeoxycorticosterone has meant different things to different people, evolving and adapting as the world changes. With this article, we seek to shed light on Tetrahydrodeoxycorticosterone and provide a comprehensive overview that allows our readers to better understand its meaning and relevance today.
Clinical data | |
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Other names | THDOC |
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ECHA InfoCard | 100.008.457 |
Chemical and physical data | |
Formula | C21H34O3 |
Molar mass | 334.500 g·mol−1 |
3D model (JSmol) | |
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Tetrahydrodeoxycorticosterone (abbreviated as THDOC; 3α,21-dihydroxy-5α-pregnan-20-one), also referred to as allotetrahydrocorticosterone, is an endogenous neurosteroid. It is synthesized from the adrenal hormone deoxycorticosterone by the action of two enzymes, 5α-reductase type I and 3α-hydroxysteroid dehydrogenase. THDOC is a potent positive allosteric modulator of the GABAA receptor, and has sedative, anxiolytic and anticonvulsant effects. Changes in the normal levels of this steroid particularly during pregnancy and menstruation may be involved in some types of epilepsy (catamenial epilepsy) and premenstrual syndrome, as well as stress, anxiety and depression.