In today's world, Monastrol remains a fundamental and intriguing topic that attracts the attention of academics, scientists, professionals and enthusiasts alike. The importance of Monastrol is manifested in different areas, from medicine to technology, through politics and culture. Throughout history, Monastrol has been the subject of study and debate, demonstrating its relevance and impact on society. In this article, we will explore different aspects related to Monastrol, from its origin and evolution to its current influence, with the aim of providing a comprehensive view of this fascinating and constantly changing topic.
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IUPAC name
ethyl 4-(3-hydroxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
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Other names
Monastrol
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Identifiers | |
3D model (JSmol)
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ChEBI | |
ChEMBL | |
ChemSpider | |
PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C14H16N2O3S | |
Molar mass | 292.35344 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
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Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin-5 (also known as KIF11, Kinesin Eg5), a motor protein important for spindle bipolarity.
Monastrol binds to a long loop that is specific to the Eg5 (also known as KIF11 or kinesin-5) kinesin family, and allosterically inhibits ATPase activity of the kinesin