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Clopimozide

In today's world, Clopimozide is a topic that arouses interest and debate in different areas. From politics to technology, Clopimozide has captured the attention of millions of people around the world, generating passionate discussions and conflicting opinions. Whether due to its impact on society, its historical relevance or its influence on people's daily lives, Clopimozide has become a central topic in current conversations. In this article, we will explore different aspects related to Clopimozide, from its origins to its possible consequences, with the aim of offering a broad and complete vision of this phenomenon that intrigues us so much.

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Clopimozide
Clinical data
ATC code
  • none
Identifiers
  • 3--4-piperidyl]-6-chloro-1H-benzimidazol-2-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC28H28ClF2N3O
Molar mass496.00 g·mol−1
3D model (JSmol)
  • Fc1ccc(cc1)C(c2ccc(F)cc2)CCCN5CCC(N4c3ccc(Cl)cc3NC4=O)CC5
  • InChI=1S/C28H28ClF2N3O/c29-21-7-12-27-26(18-21)32-28(35)34(27)24-13-16-33(17-14-24)15-1-2-25(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24-25H,1-2,13-17H2,(H,32,35)
  • Key:JCZYXTVBWHAWLL-UHFFFAOYSA-N

Clopimozide (R-29,764) is a typical antipsychotic drug of the diphenylbutylpiperidine class.[1][2] It is very potent and has an extremely long duration of action, lasting at least one week with a single dose.[3][4][5] It was developed by Janssen Pharmaceutica but was never marketed.

See also

References

  1. ^ De Cuyper HJ, Van Praag HM, Mulder WR (May 1979). "Therapeutical significance of clopimozide in the treatment of chronic psychotic patients". Acta Psychiatrica Scandinavica. 59 (5): 561–74. doi:10.1111/j.1600-0447.1979.tb00256.x. PMID 37697. S2CID 30954603.
  2. ^ Knapen J, Bollen J, Brugmanns J, Rombaut N (1976). "". Acta Psychiatrica Belgica (in French). 76 (4): 644–57. PMID 798469.
  3. ^ Janssen PA, Niemegeers CJ, Schellekens KH, Lenaerts FM, Wauquier A (August 1975). "Clopimozide (R 29 764), a new highly potent and orally long-acting neuroleptic of the diphenylbutylpiperidine series". Arzneimittel-Forschung. 25 (8): 1287–94. PMID 1242360.
  4. ^ Floru L, Tegeler J (1978). "Clinical experiments with the new oral long-acting neuroleptic clopimozide (R 29 764)". Arzneimittel-Forschung. 28 (2): 341–4. PMID 25071.
  5. ^ Bobon J, Parent M, Toussaint C, Pinchard A (1976). "". Acta Psychiatrica Belgica (in French). 76 (1): 138–43. PMID 970182.


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