BMS-906024

In this article, we will explore BMS-906024 from different perspectives and in various contexts. BMS-906024 is a topic that has sparked interest and debate over time, and its relevance continues to be evident today. Through this article, we will delve into the multiple aspects that BMS-906024 encompasses, addressing its implications, its history, its impact on today's society, as well as the possible perspectives offered by experts and scholars on the subject. Likewise, we will examine different opinions and points of view in relation to BMS-906024, with the purpose of providing the reader with a complete and enriching vision on this topic.

BMS-906024
Identifiers
  • (2R,3S)-N--2,3-bis(3,3,3-trifluoropropyl)succinamide
CAS Number
PubChem CID
PubChem SID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC26H26F6N4O3
Molar mass556.509 g·mol−1
3D model (JSmol)
  • CN1c2ccccc2C(=N(C1=O)NC(=O)(CCC(F)(F)F)(CCC(F)(F)F)C(=O)N)c3ccccc3
  • InChI=1S/C26H26F6N4O3/c1-36-19-10-6-5-9-18(19)20(15-7-3-2-4-8-15)34-22(24(36)39)35-23(38)17(12-14-26(30,31)32)16(21(33)37)11-13-25(27,28)29/h2-10,16-17,22H,11-14H2,1H3,(H2,33,37)(H,35,38)/t16-,17+,22+/m0/s1
  • Key:AYOUDDAETNMCBW-GSHUGGBRSA-N

BMS-906024 is a drug with a benzodiazepine structure, developed by Bristol-Myers Squibb and disclosed at the spring 2013 American Chemical Society meeting in New Orleans to treat breast, lung, colon cancers and leukemia. The drug works as a pan-Notch inhibitor. The structure is one of a set patented in 2012, and is being studied in clinical trials.

References

  1. ^ Drahl C (2013). "Liveblogging First-Time Disclosures of Drug Structures from #ACSNOLA". Chemical and Engineering News. American Chemical Society.
  2. ^ WO 2012129353, Quesnelle C, Kim SH, Lee F, Gavai A, "Bisfluoroalkyl-1,4-Benzodiazepinone Compounds", published 27 September 2012, assigned to Bristol-Myers Squibb Company 
  3. ^ Gavai AV, Quesnelle C, Norris D, Han WC, Gill P, Shan W, et al. (May 2015). "Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors". ACS Medicinal Chemistry Letters. 6 (5): 523–7. doi:10.1021/acsmedchemlett.5b00001. PMC 4434460. PMID 26005526.
  4. ^ Morgan KM, Fischer BS, Lee FY, Shah JJ, Bertino JR, Rosenfeld J, et al. (December 2017). "Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma". Molecular Cancer Therapeutics. 16 (12): 2759–2769. doi:10.1158/1535-7163.MCT-17-0439. PMC 5716926. PMID 28978720.
  5. ^ Sosa Iglesias V, Theys J, Groot AJ, Barbeau LM, Lemmens A, Yaromina A, et al. (2018). "Synergistic Effects of NOTCH/γ-Secretase Inhibition and Standard of Care Treatment Modalities in Non-small Cell Lung Cancer Cells". Frontiers in Oncology. 8: 460. doi:10.3389/fonc.2018.00460. PMC 6234899. PMID 30464927.
Stub icon

This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.

Wikious
Boobota
Sagapedia