Lofendazam

Today, Lofendazam is a topic that has gained great relevance in different sectors of society. Its impact can be observed in the personal, economic, political, cultural and technological spheres, among others. Lofendazam has caught the attention of experts and scholars, as well as individuals who wish to better understand its influence on everyday life. Throughout history, Lofendazam has experienced changes and transformations that have given rise to debates and reflections on its meaning and scope. In this article, we will explore the impact of Lofendazam on contemporary society and analyze its implications in different areas.

Lofendazam
Clinical data
ATC code
  • none
Identifiers
  • 8-chloro-1-phenyl-1,3,4,5-tetrahydro- 2H-1,5-benzodiazepin- 2-one
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.044.975 Edit this at Wikidata
Chemical and physical data
FormulaC15H13ClN2O
Molar mass272.73 g·mol−1
3D model (JSmol)
  • Clc3ccc1c(N(C(=O)CCN1)c2ccccc2)c3
  • InChI=1S/C15H13ClN2O/c16-11-6-7-13-14(10-11)18(15(19)8-9-17-13)12-4-2-1-3-5-12/h1-7,10,17H,8-9H2 checkY
  • Key:IUJQOUHDFKALCY-UHFFFAOYSA-N checkY
  (verify)

Lofendazam is an organic molecule which is a benzodiazepine derivative. Lofendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring; therefore, lofendazam is most closely related to other 1,5-benzodiazepines such as clobazam.

Lofendazam as a human pharmaceutical has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives. It is an active metabolite of another benzodiazepine, arfendazam.

See also

References

  1. ^ DE 1929656 
  2. ^ Malik F, Hasan M, Khan KM, Perveen S, Snatzke G, Duddeck H, Voelter W (1995). "Syntheses and CD studies of optically active substituted 1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-ones". Liebigs Annalen der Chemie. 1995 (10): 1861–1869. doi:10.1002/jlac.1995199510261.
  3. ^ Aversa MC, Giannetto P, Romeo G, Ficarra P, Vigorita MG (1981). "Nuclear magnetic resonance spectra of psychotherapeutic agents. V* - conformational analysis of 1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-ones". Organic Magnetic Resonance. 15 (4): 394–398. doi:10.1002/mrc.1270150414.
  4. ^ Adrien J, Albani F, Baruzzi A, Berger M, Bixler EO, Borbeley AA, Dikeos DG, Drucker-Colin R, Montero RF, Hishikawa Y, Inoue S (11 December 1995). The Pharmacology of Sleep. Springer. ISBN 978-3-540-58961-7.
Wikious
Boobota
Sagapedia