Clotizolam

Today, Clotizolam is a topic of great relevance and interest to many people around the world. Since ancient times, Clotizolam has been the object of study, debate and reflection, and its impact covers various aspects of daily life. Currently, the importance of Clotizolam has been enhanced by the rise of new technologies, which have opened new perspectives of analysis and understanding on this topic. In this article, we will explore different aspects of Clotizolam, from its origin to its relevance today, through its implications in different areas of social, cultural, economic and political life.

Clotizolam
Legal status
Legal status
Identifiers
  • 2-Chloro-4-(2-chlorophenyl)-9-methyl-6H-thienotriazolodiazepine
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H10Cl2N4S
Molar mass349.23 g·mol−1
3D model (JSmol)
Melting point205 °C (401 °F)
  • CC1=NN=C2N1C3=C(C=C(S3)Cl)C(=NC2)C4=CC=CC=C4Cl
  • InChI=1S/C15H10Cl2N4S/c1-8-19-20-13-7-18-14(9-4-2-3-5-11(9)16)10-6-12(17)22-15(10)21(8)13/h2-6H,7H2,1H3
  • Key:CHGXYVPOFYZWRH-UHFFFAOYSA-N

Clotizolam (Ro11-1465) is a thienotriazolodiazepine derivative first invented in the 1970s, which in more recent years has been sold as a designer drug. As with other related thienotriazolodiazepines, it produces sedative, anxiolytic, anticonvulsant and muscle relaxant effects, and also acts as an inhibitor of platelet-activating factor (PAF).

See also

References

  1. ^ US 4155913, Hellerbach J, Zeller P, Binder D, Hromatka O, "Thienotriazolodiazepine derivatives", issued 22 May 1979, assigned to Hoffmann La Roche Inc. 
  2. ^ Tahara T, Mikashima H, Terasawa M, Maruyama Y (May 1987). "PAF antagonistic activity of some thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines". Chemical & Pharmaceutical Bulletin. 35 (5): 2119–21. doi:10.1248/cpb.35.2119. PMID 3664818. S2CID 27564672.