Ciclotizolam

In today's article we are going to talk about Ciclotizolam, an exciting and relevant topic today. Ciclotizolam is a topic that has generated great interest and debate in different areas, from politics to science, including the world of entertainment and culture. Whether due to its impact on society, its historical relevance or its influence on people's daily lives, Ciclotizolam continues to be a relevant topic that does not leave anyone indifferent. In this article we will explore different aspects of Ciclotizolam, analyze its importance and impact today, and try to shed light on a topic that concerns us all.

Ciclotizolam
Ball-and-stick model of the ciclotizolam molecule
Clinical data
ATC code
  • none
Legal status
Legal status
Identifiers
  • 8-bromo-6-(o-chlorophenyl)-1-cyclohexyl-4H-5-triazolo(3,4-c)thieno(2,4-e)-1,4-diazepine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC20H18BrClN4S
Molar mass461.81 g·mol−1
3D model (JSmol)
  • Clc5ccccc5C/2=N/Cc1nnc(n1c3sc(Br)cc\23)C4CCCCC4
  • InChI=1S/C20H18BrClN4S/c21-16-10-14-18(13-8-4-5-9-15(13)22)23-11-17-24-25-19(26(17)20(14)27-16)12-6-2-1-3-7-12/h4-5,8-10,12H,1-3,6-7,11H2 checkY
  • Key:ZOSHXIXUCKESEG-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Ciclotizolam (WE-973) is a drug which is a thienotriazolodiazepine derivative. It is a partial agonist for the benzodiazepine site of the GABAA receptor, with similar binding affinity to related compounds like brotizolam, but a low efficacy.

See also

References

  1. ^ DE Patent 2445430
  2. ^ Weber KH, Kuhn FJ, Böke-Kuhn K, Lehr E, Danneberg PB, Hommer D, Paul SM, Skolnick P (February 1985). "Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles ('hetrazepines')". European Journal of Pharmacology. 109 (1): 19–31. doi:10.1016/0014-2999(85)90535-7. PMID 2986988.
  3. ^ Ikeda M, Weber KH, Bechtel WD, Malatynska E, Yamamura HI (1989). "Relative efficacies of 1,4-diazepines on GABA-stimulated chloride influx in rat brain vesicles". Life Sciences. 45 (4): 349–58. doi:10.1016/0024-3205(89)90145-8. PMID 2569655.
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