Thienotriazolodiazepine

In this article, we will explore Thienotriazolodiazepine from different perspectives, analyzing its importance, impact and relevance in various contexts. From its origin to its evolution today, Thienotriazolodiazepine has been the subject of interest and debate among experts, academics and hobbyists. Through a detailed analysis, we aim to shed light on the lesser-known aspects of Thienotriazolodiazepine, as well as highlight its influence in fields as varied as science, culture, technology or society in general. With a multidisciplinary approach, we will address the multiple facets of Thienotriazolodiazepine to provide a comprehensive and enriching vision on this topic.

Chemical compound

Not to be confused with thienobenzodiazepine or thienodiazepine.

A thienotriazolodiazepine is a heterocyclic compound containing a diazepine ring fused to thiophene and triazole rings. Thienotriazolodiazepine forms the central core of several pharmaceutical drugs including:

• α-Hydroxyetizolam
• Brotizolam
• Ciclotizolam
• Clotizolam
• Deschloroclotizolam
• Deschloroetizolam
• Etizolam
• Flubrotizolam
• Fluclotizolam
• Fluetizolam
• Metizolam

Thienotriazolodiazepines interact with the benzodiazepine receptor site, they typically have similar effects as 1,4-benzodiazepines (such as diazepam) and triazolobenzodiazepines (such as alprazolam).

Thienotriazolodiazepines that are not GABA_A receptor positive allosteric modulators include:

• Apafant
• Israpafant
• JQ1

References

1. ^ Catabay, A.; Taniguchi, M.; Jinno, K.; Pesek, J. J.; Williamsen, E. (1 March 1998). "Separation of 1,4-Benzodiazepines and Analogues Using Cholesteryl-10-Undecenoate Bonded Phase in Microcolumn Liquid Chromatography". Journal of Chromatographic Science. 36 (3): 113. doi:10.1093/chromsci/36.3.111.
2. ^ Hirota, N; Yasuda, D; Hashidate, T; Yamamoto, T; Yamaguchi, S; Nagamune, T; Nagase, T; Shimizu, T; Nakamura, M (Feb 2010). "Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor". Journal of Biological Chemistry. 285 (8): 5931–40. doi:10.1074/jbc.M109.066282. PMC 2820818. PMID 20007715.

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