Nitemazepam

The topic of Nitemazepam is one that has been widely discussed over the years. With divergent opinions and varied points of view, Nitemazepam has captured the interest of experts and enthusiasts alike. In this article, we will explore the different facets of Nitemazepam, offering a comprehensive analysis covering its history, impact, and possible implications for the future. From its origin to its current evolution, Nitemazepam has left a significant mark on the world that deserves meticulous and detailed attention.

Benzodiazepine designer drug

Not to be confused with nimetazepam or temazepam.

Nitemazepam

Legal status
Legal status	CA: Schedule IV DE: NpSG (Industrial and scientific use only) UK: Under Psychoactive Substances Act
Identifiers
IUPAC name 7-nitro-3-hydroxy-5-phenyl-1-methyl-1H-benzo diazepin-2(3H)-one
CAS Number	40762-03-6
PubChem CID	12362353
ChemSpider	64854354
UNII	DFJ6M9363O
Chemical and physical data
Formula	C16H13N3O4
Molar mass	311.297 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=(O)c1ccc2c(c1)C(=NC(O)C(=O)N2C)c3ccccc3
InChI InChI=1S/C16H13N3O4/c1-18-13-8-7-11(19(22)23)9-12(13)14(17-15(20)16(18)21)10-5-3-2-4-6-10/h2-9,15,20H,1H3 Key:QRWVNMAJJIQCEG-UHFFFAOYSA-N

Nitemazepam (or 3-hydroxynimetazepam) is a benzodiazepine derivative which was first synthesised in the 1970s but was never marketed. It is the 7-nitro instead of 7-chloro analogue of temazepam, and also the 3-hydroxy derivative of nimetazepam, and an active metabolite. It has in more recent years been sold as a designer drug, first being definitively identified in Europe in 2017. It is metabolized to 7-aminonitemazepam, nimetazepam, 3-hydroxynitemazepam, temazepam, and nimetazepam glucuronide.

References

1. ^ Zawilska JB, Wojcieszak J (July 2019). "An expanding world of new psychoactive substances-designer benzodiazepines". Neurotoxicology. 73: 8–16. doi:10.1016/j.neuro.2019.02.015. PMID 30802466. S2CID 73461430.
2. ^ Moosmann B, Auwärter V (2018). "Designer Benzodiazepines: Another Class of New Psychoactive Substances.". In Maurer H, Brandt S (eds.). New Psychoactive Substances. Handbook of Experimental Pharmacology. Vol. 252. pp. 383–410. doi:10.1007/164_2018_154. ISBN 978-3-030-10560-0. PMID 30367253.