Nitrazolam

In this article we are going to explore the impact of Nitrazolam on today's society. For decades, Nitrazolam has been a topic of interest to academics, experts and the general public. Its relevance has been reflected in different areas such as politics, culture, economy and technology. Over time, Nitrazolam has proven its ability to create meaningful change and provoke passionate debate. In this sense, it is essential to critically and objectively analyze the role that Nitrazolam plays in our society and how it continues to shape our present and future.

Not to be confused with nitrazepam.
Nitrazolam
Legal status
Legal status
Identifiers
  • 1-methyl-8-nitro-6-phenyl-4H-triazolobenzodiazepine
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC17H13N5O2
Molar mass319.324 g·mol−1
3D model (JSmol)
  • Cc1nnc2CN=C(c3ccccc3)c4cc(ccc4n12)()=O
  • InChI=1S/C17H13N5O2/c1-11-19-20-16-10-18-17(12-5-3-2-4-6-12)14-9-13(22(23)24)7-8-15(14)21(11)16/h2-9H,10H2,1H3
  • Key:OYRPNABWTHDOFK-UHFFFAOYSA-N

Nitrazolam is a triazolobenzodiazepine (TBZD) , which are benzodiazepine (BZD) derivatives, that has been sold online as a designer drug.

It is closely related to clonazolam or flunitrazolam, only differing by the removal of a chlorine or fluorine group respectively at the benzene ring.

A study in mice indicated that nitrazolam can be several times more potent than diazepam as an antagonist of electroshock-induced tonic-extensor convulsions but less potent than diazepam at preventing the righting reflex.

Nitrazolam has been used as an example compound to demonstrate the microscale synthesis of reference materials utilizing polymer‐supported reagents.

Legal status

United Kingdom

In the UK, nitrazolam has been classified as a Class C drug by the May 2017 amendment to The Misuse of Drugs Act 1971 along with several other designer benzodiazepine drugs.

See also

References

  1. ^ Hester Jr JB (19 October 1976). "Patent US3987052 - 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines". The Upjohn Company.
  2. ^ "Nitrazolam". New Synthetic Drugs Database.
  3. ^ Moosmann B, Bisel P, Franz F, Huppertz LM, Auwärter V (November 2016). "Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines - an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam and nitrazolam". Journal of Mass Spectrometry. 51 (11): 1080–1089. Bibcode:2016JMSp...51.1080M. doi:10.1002/jms.3840. PMID 27535017.
  4. ^ Hester JB, Rudzik AD, Kamdar BV (November 1971). "6-phenyl-4H-s-triazolobenzodiazepines which have central nervous system depressant activity". Journal of Medicinal Chemistry. 14 (11): 1078–81. doi:10.1021/jm00293a015. PMID 5165540.
  5. ^ Dowling G, Kavanagh PV, Eckhardt HG, Twamley B, Hessman G, McLaughlin G, et al. (March 2018). "An approach to shortening the timeframe between the emergence of new compounds on the drugs market and the availability of reference standards: The microscale syntheses of nitrazolam and clonazolam for use as reference materials, utilizing polymer-supported reagents" (PDF). Drug Testing and Analysis. 10 (7): 1198–1208. doi:10.1002/dta.2383. PMID 29542872. S2CID 205763816.
  6. ^ "The Misuse of Drugs Act 1971 (Amendment) Order 2017".
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