Arfendazam

This article will address the topic of Arfendazam, which has currently generated great interest. Since its inception, Arfendazam has been the subject of analysis and debate in different areas, generating conflicting opinions and diverse positions. Given the relevance and complexity of Arfendazam, it is essential to deepen its study to understand its impact and implications in today's society. In this sense, an exhaustive analysis of Arfendazam will be carried out, addressing its most relevant aspects and offering a comprehensive vision that allows the reader to delve into its meaning and scope. In addition, different perspectives and approaches will be considered that contribute to enriching the understanding of Arfendazam, thus providing a global and multifaceted vision of this broad and significant topic.

Arfendazam
Clinical data
ATC code
  • none
Identifiers
  • Ethyl 7-chloro-4-oxo-5-phenyl-2,3-dihydro-1,5-benzodiazepine-1-carboxylate
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.048.694 Edit this at Wikidata
Chemical and physical data
FormulaC18H17ClN2O3
Molar mass344.80 g·mol−1
3D model (JSmol)
  • ClC1=CC2=C(C=C1)N(CCC(N2C3=CC=CC=C3)=O)C(OCC)=O
  • InChI=1S/C18H17ClN2O3/c1-2-24-18(23)20-11-10-17(22)21(14-6-4-3-5-7-14)16-12-13(19)8-9-15(16)20/h3-9,12H,2,10-11H2,1H3 checkY
  • Key:NXJWVCHVPUCWJS-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Arfendazam (INN) is a drug which is a benzodiazepine derivative. Arfendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring, and so is most closely related to other 1,5-benzodiazepines such as clobazam.

Arfendazam has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, but is a partial agonist at GABAA receptors, so the sedative effects are relatively mild and it produces muscle relaxant effects only at very high doses.

Arfendazam produces an active metabolite lofendazam, which is thought to be responsible for part of its effects.

See also

References

  1. ^ "International Nonproprietary Names for Pharmaceutical Substances. Proposed International Nonproprietary Names (Prop. INN): List 39. Supplement to WHO Chronicle" (PDF). World Health Organization. March 1978. p. 3. Retrieved 4 December 2015.
  2. ^ Mueller E (January 1985). "Benzodiazepine receptor interactions of arfendazam, a novel 1, 5-benzodiazepine". Pharmacopsychiatry. 18 (1): 10–1. doi:10.1055/s-2007-1017288. S2CID 144951247.
  3. ^ Müller WE, Groh B, Bub O (July 1986). "In vitro and in vivo studies of the mechanism of action of arfendazam, a novel 1, 5-benzodiazepine". Pharmacopsychiatry. 19 (4): 314–315. doi:10.1055/s-2007-1017251. S2CID 143919337.
  4. ^ Adrien J, Albani F, Baruzzi A, Berger M, Bixler EO, Borbeley AA, Dikeos DG, Drucker-Colin R, Montero RF, Hishikawa Y, Inoue S (December 2012). The Pharmacology of Sleep. Springer Science & Business Media. ISBN 978-3-540-58961-7.


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