In this article we will explore Etiocholanolone in depth, a topic that has captured the attention of many in recent times. As we delve into this exciting topic, we will try to shed light on its importance and relevance in today's world. From its origins to its impact on society, Etiocholanolone has been the subject of debate and analysis, and in this article we will try to address all its facets in an objective and detailed manner. Through a multidisciplinary approach, we will examine the historical, cultural and contemporary aspects of Etiocholanolone, with the goal of providing our readers with a broader and deeper understanding of this fascinating topic.
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Other names | Aetiocholanolone 5-Isoandrosterone |
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Formula | C19H30O2 |
Molar mass | 290.447 g·mol−1 |
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Etiocholanolone, also known as 5β-androsterone, as well as 3α-hydroxy-5β-androstan-17-one or etiocholan-3α-ol-17-one, is an etiocholane (5β-androstane) steroid as well as an endogenous 17-ketosteroid that is produced from the metabolism of testosterone. It causes fever, immunostimulation, and leukocytosis, and is used to evaluate adrenal cortex function, bone marrow performance, and in neoplastic disease to stimulate the immune system. Etiocholanolone is also known to be an inhibitory androstane neurosteroid, acting as a positive allosteric modulator of the GABAA receptor, and possesses anticonvulsant effects. The unnatural enantiomer of etiocholanolone is more potent as a positive allosteric modulator of GABAA receptors and as an anticonvulsant than the natural form.
Etiocholanolone has been studied as a pyrogenic steroid in the so-called steroid fever (or etiocholanolone fever), a condition similar to familial mediterranean fever (FMF). Etiocholanolone (like pregnanolone) activates the pyrin inflammasome. It is not known whether these endogenous steroids play a role in triggering FMF flares but they may make a link between stress, menstrual cycle and disease flares.
Etiocholanolone is produced from 5β-dihydrotestosterone, with 3α,5β-androstanediol as an intermediate.
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