Hydroxydione

This article will address the topic of Hydroxydione, which has been the subject of interest and debate in various areas. Hydroxydione has aroused the interest of experts and the general public due to its relevance and impact in different areas. Throughout history, Hydroxydione has been the object of study and analysis, which has allowed us to delve deeper into its meaning and significance. In this sense, it is essential to delve into the different approaches and perspectives that exist around Hydroxydione, in order to understand its importance and contribution in the field in which it operates. This article aims to provide a broad and detailed vision of Hydroxydione, providing elements that enrich knowledge and promote a critical and reflective analysis of this topic.

Hydroxydione
Clinical data
Trade namesViadril, Predion, Presuren
Other names21-Hydroxy-5β-pregnane-3,20-dione
ATC code
  • None
Legal status
Legal status
  • BR: Class C1 (Other controlled substances)
Identifiers
  • (5R,8R,9S,10S,13S,14S,17S)-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopentaphenanthren-3-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
Chemical and physical data
FormulaC21H32O3
Molar mass332.484 g·mol−1
3D model (JSmol)
  • C12CCC(=O)C1CC32CC4(3CC4C(=O)CO)C
  • InChI=1S/C21H32O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h13,15-18,22H,3-12H2,1-2H3/t13-,15+,16+,17+,18-,20+,21+/m1/s1
  • Key:USPYDUPOCUYHQL-VEVMSBRDSA-N

Hydroxydione, as hydroxydione sodium succinate (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name, BANTooltip British Approved Name) (brand names Viadril, Predion, and Presuren), also known as 21-Hydroxy-5β-pregnane-3,20-dione, is a neuroactive steroid which was formerly used as a general anesthetic, but was discontinued due to incidence of thrombophlebitis in patients. It was introduced in 1957, and was the first neuroactive steroid general anesthetic to be introduced for clinical use, an event which was shortly preceded by the observation in 1954 of the sedative properties of progesterone in mice.

Chemistry

See also: List of neurosteroids

Related compounds include alfadolone, alfaxolone, dihydrodeoxycorticosterone, ganaxolone, minaxolone, pregnanolone, and renanolone.

References

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 531–. ISBN 978-3-88763-075-1.
  3. ^ Kar A (1 January 2005). Medicinal Chemistry. New Age International. pp. 63–. ISBN 978-81-224-1565-0.
  4. ^ a b William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 1863–. ISBN 978-0-8155-1856-3.
  5. ^ Edmond II IE, Saidman L, Westhorpe R (14 September 2013). The Wondrous Story of Anesthesia. Springer Science & Business Media. pp. 632–. ISBN 978-1-4614-8441-7.
  6. ^ Dorfman RI (22 October 2013). Steroidal Activity in Experimental Animals and Man. Elsevier Science. pp. 447–. ISBN 978-1-4832-7299-3.


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